PikaCRAM

Acetoacetic Ester Synthesis

Fischer Esterification


Wolff-Kishner Reduction

Wittig Reaction


Oxidation reaction.

alcohols/1-butanol PCC,CH2Cl2 aldehydes/butanal

Clemmensen Reduction

Grignard reaction.

halides/bromobutane Mg,ether,H2CO,H3O+wu alcohols/pentanol

Imine formation.

ketones/acetophenone amines/CH3CH2NH2 H3O+,double_arrow amines/imine(2)

Aldol reaction.

carbonyls/2_eq_of_cyclohexanone NaOH,heat carbonyls/2,5-dehydrocyclohexylcyclohexanone
Alkenes

Brown Hydroboration

The syn-addition of hydroboranes to alkenes occurs with predictable selectivity, wherein the boron adds preferentially to the least hindered carbon. This selectivity is enhanced if sterically demanding boranes are used.

Diels-Alder Reaction


Bromination.

AlkeneReactions/ALKENEG1 ../AlkeneReactions/ALKENEGC AlkeneReactions/ALKENEG2

Epoxidation.

alkenes/cycloheptene MCPBA alkanes/1,2-epoxycycloheptane

Ozonolysis.

alkenes/6methylheptene O3,Zn,CH3COOH aldehydes/aldehydeproducts1

Markovnikov alcohol formation.

AlkeneReactions/ALKENEE1 ../AlkeneReactions/ALKENEEC AlkeneReactions/ALKENEE2
Amines

Hofmann Elimination.

amines/piperidine CH3I,Ag2O,H2O,heat amines/NNdimethylpenteneamine acid-base/H2O

Gabriel Synthesis


Alocohols

Alcohol to Tosylate.

alcohols/cyclohexanol TosCl,pyridine alkanes/cyclohexyl_tosylate

Williamson Synthesis

Alcohol oxidation.

alcohols/1,6-decalindiol misc/Pb(OAc)4 ../utility/arrow ketones/1,6-cyclodecadione

Cyanide Addition.

alcohols/allylic_tosylate NaCN misc/allylic_cyanate 
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